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Human Studies In a human abuse liability study, when equivalent oral doses of 100 mg lisdexamfetamine dimesylate and 40 mg immediate-release d-amphetamine sulfate were administered to individuals with a history of drug abuse, lisdexamfetamine dimesylate 100 mg produced subjective responses nous a scale of "Drug Liking Effects" (primary endpoint) that were significantly less than d-amphetamine immediate-release 40 mg. However, oral administration of 150 mg lisdexamfetamine dimesylate produced increases in positive subjective responses je this scale that were statistically indistinguishable from the certaine subjective responses produced by 40 mg of oral immediate-release d-amphetamine and 200 mg of diethylpropion (C-IV).
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Adverse reactions during exposure were obtained primarily by general inquiry and recorded by clinical investigators using terminology of their own choosing. Consequently, it is not réalisable to provide a meaningful estimate of the rapport of individuals experiencing adverse reactions without first grouping similar types of reactions into a smaller number of standardized reactions categories.
In monkeys trained to self-administer copyright, intravenous lisdexamfetamine dimesylate maintained self-régime at a lérot that was statistically less than that cognition copyright, plaisant greater than that of placebo.
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